Table 2 Multivariate linear regression models of the relationship between homocysteine and MMSE score

ModelSubjects <65, Δ in MMSEp ValueSubjects ≥65, Δ in MMSEp Value
* Model 1: continuous = age, creatinine, log tHcy*creatinine; categorical = age, creatinine, categorical tHcy*creatinine.
† Model 2 = model 1, B-12 deficiency (MMA > 271 nmol/L), sex, race ethnicity, education, Medicaid status.
‡ Model 3 = model 2, hypertension, diabetes, cardiac disease, smoking, ethanol use, body mass index.
tHcy = fasting plasma total homocysteine level; MMSE = Mini Mental State Examination; MMA = methylmalonic acid.
Model 1*
    Continuous (log tHcy)−1.95 (−3.74, −0.17)0.032−3.48 (−4.89, −2.07)<0.001
    Categorical tHcy
        50th to 90th %ile (10–15 μmol/L)−0.23 (−2.86, 2.39)0.861−2.56 (−4.21, −0.90)0.003
        >90th %ile (>15 μmol/L)−1.36 (−3.33, 0.60)0.173−3.32 (−4.82, −1.82)<0.001
Model 2
    Continuous (log tHcy)0.03 (−1.70, 1.76)0.970−2.24 (−3.58, −0.90)0.001
    Categorical tHcy
        50th to 90th %ile (10–15 μmol/L)0.96 (−1.45, 3.37)0.435−1.16 (−2.67, 0.36)0.134
        >90th %ile (>15 μmol/L)0.68 (−1.19, 2.55)0.474−1.66 (−3.09, −0.23)0.023
Model 3
    Continuous (log tHcy)−0.0002 (−1.74, 1.74)0.9998−2.20 (−3.54, −0.86)0.001
    Categorical tHcy
        50th to 90th %ile (10–15 μmol/L)0.99 (−1.44, 3.41)0.424−0.92 (−2.43, 0.59)0.231
        >90th %ile (>15 μmol/L)0.66 (−1.21, 2.54)0.489−1.55 (−2.98, −0.13)0.033