Table Baseline characteristics of the study sample (n = 554)

Men, n = 313Women, n = 241p*
* Two-sample t-test used for continuous variates and χ2-test for categorical variates.
† Values are means (SD).
‡ Values are n (%).
§ Total WMH, PVWMH, and DWMH not normally distributed, Mann–Whitney test.
LDL = low-density lipoprotein; HDL = high-density lipoprotein; WMH = white matter hyperintensity; DWMH = deep white matter hyperintensity; PVWMH = periventricular white matter hyperintensity.
Continuous variates
    Age, y74.5 (3.1)75.6 (3.2)<0.0001
    Systolic blood pressure, mm Hg158.4 (22.6)156.7 (20.4)0.42
    Diastolic blood pressure, mm Hg85.8 (10.8)85.9 (11.4)0.97
    Total cholesterol, mmol/L5.5 (0.8)6.1 (0.9)<0.0001
    LDL cholesterol, mmol/L3.8 (0.7)4.1 (0.8)<0.0001
    HDL cholesterol, mmol/L1.2 (0.3)1.3 (0.3)<0.0001
    Triglycerides, mmol/L1.4 (0.7)1.6 (0.6)0.02
    Baseline total WMH,§ mL4.9 (9.5)5.7 (9.7)0.024
    Baseline DWMH,§ mL0.9 (1.5)1.4 (1.8)0.0009
    Baseline PVWMH,§ mL4.0 (8.5)4.3 (8.5)0.057
Categorical variates
    Current smoker84 (26.8)31 (12.7)<0.0001
    History of diabetes54 (17.3)37 (15.4)0.55
    History of hypertension164 (52.4)186 (77.2)<0.0001
    History of myocard infarction52 (16.6)15 (6.2)0.0002
    History of stroke or TIA49 (15.7)41 (17.0)0.67
    History of any vascular disease153 (48.9)88 (36.5)0.0036
    Baseline MRI stroke122 (39.2)91 (38.4)0.84
    Pravastatin150 (47.9)125 (51.9)0.36